Research Research Projects / Summary

LEO’s methodological principles [see Methodology] are applied in the context of two main research topics:

BRAIN ASYMMETRY
	Despite the relevance of asymmetry in normal and affected brain function, the mechanism by which it is established during development has been largely elusive. LEO's scientific approach uses the epithalamus of zebrafish and medaka as a main model system to address the ontogenic mechanisms of brain asymmetry, applying a bottom-up (gene to behaviour) comparative analysis. [more]
CELLULAR MORPHOGENESIS
	The dynamic transformation of the embryo from an amorph mass of cells into an ordered shaped body requires the coordinated activity of individual cells and cell groups. LEO's scientific approach uses different cellular models in zebrafish and annual fish to address the ontogenic mechanisms of individual and collective cell reorganisation during development, organogenesis and disease. [more]